From the USA: Tumor-Infiltrating Lymphocyte Abundance Prognostic in Early-Stage TNBC

For patients with early-stage triple-negative breast cancer (TNBC) who undergo surgery without chemotherapy, tumor-infiltrating lymphocyte (TIL) abundance is associated with improved survival, according to a study published online April 2 in the Journal of the American Medical Association.

Roberto A. Leon-Ferre, M.D., from the Mayo Clinic in Rochester, Minnesota, and colleagues examined the association of TIL abundance in breast cancer tissue with survival among patients with early-stage TNBC who were treated with locoregional therapy in a retrospective pooled analysis of individual patient-level data from 13 participating centers. A total of 1,966 participants diagnosed with TNBC between 1979 and 2017 who received treatment with surgery, with or without radiotherapy but without chemotherapy, were included.

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