Directly from the USA: Differences ID’d in Tau Burden in Down Syndrome, Alzheimer Disease

The spatial distribution, timing, and magnitude of tau burden differs for people with Down syndrome and those with autosomal-dominant Alzheimer disease, according to a study published in the May issue of The Lancet Neurology.

Julie K. Wisch, Ph.D., from Washington University in St. Louis, and colleagues conducted a cross-sectional observational study to compare the magnitude, spatial extent, and temporal ordering of tau spread in people with Down syndrome and autosomal-dominant Alzheimer disease and in noncarrier familial controls. All participants completed structural magnetic resonance imaging and tau positron emission tomography (PET) imaging.

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