USA: Testosterone Treatment Does Not Cut Fracture Incidence in Men With Hypogonadism

Testosterone treatment does not result in a lower incidence of clinical fractures among middle-aged and older men with hypogonadism, according to a study published in the Jan. 18 issue of the New England Journal of Medicine.

Peter J. Snyder, M.D., from the Perelman School of Medicine at the University of Pennsylvania in Philadelphia, and colleagues examined the risk for clinical fracture in a time-to-event analysis subtrial of a randomized placebo-controlled trial that evaluated the cardiovascular safety of testosterone treatment in middle-aged and older men with hypogonadism. Eligible men were aged 45 to 80 years with preexisting, or a high risk for, cardiovascular disease; one or more symptoms of hypogonadism; and two morning testosterone concentrations <300 ng/dL in fasting plasma samples obtained at least 48 hours apart. A total of 5,204 participants were randomly assigned to apply testosterone or placebo gel daily (2,601 and 2,603, respectively).

Source: Advances and More licensed by HealthDay