USA: Neoantigen DNA Vaccines Safe, Induce Response in Triple-Negative Breast Cancer
Neoantigen DNA vaccines are safe and capable of inducing neoantigen-specific immune responses in patients with triple-negative breast cancer, according to a study published online Nov. 14 in Genome Medicine.
Xiuli Zhang, M.D., from the Washington University School of Medicine in St. Louis, and colleagues developed a neoantigen DNA vaccine platform capable of presenting human leukocyte antigen class I and II epitopes. Tumor/normal exome sequencing and tumor RNA sequencing were used to identify expressed somatic mutations; cancer neoantigens were identified and prioritized using neoantigen prediction algorithms in order to facilitate vaccine design. The neoadjuvant DNA vaccines were administered in the adjuvant setting in a phase 1 clinical trial involving triple-negative breast cancer patients with persistent disease on surgical pathology following neoadjuvant chemotherapy. Vaccines were monitored for safety and immune responses.
Source: Advances and More licensed by HealthDay
