USA: Genetic Factors Influence Subsequent Cancer Risk in Childhood Cancer Survivors

Polygenic risk scores (PRSs) derived from the general population are associated with a subsequent risk for certain cancers among survivors of childhood cancer, with an additive risk for PRS and radiotherapy, according to a study published online March 7 in Nature Medicine.

Todd M. Gibson, Ph.D., from the National Cancer Institute in Bethesda, Maryland, and colleagues examined the impact of genetic predisposition on the risk for subsequent cancers among survivors of childhood cancer. Genotype data were combined for 11,220 five-year survivors from the Childhood Cancer Survivor Study and the St. Jude Lifetime Cohort.

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