Reporting from the USA: Most Patients With Stage I PDAC Are Upstaged on Histopathology
More than 70 percent of patients with stage I pancreatic ductal adenocarcinoma (PDAC) and close to 30 percent with stage II PDAC are upstaged on histopathology, according to a research letter published online Sept. 5 in the Journal of the American Medical Association.
Gerardo Perrotta, M.D., from Cedars-Sinai Medical Center in Los Angeles, and colleagues examined the accuracy of clinical staging in early-stage PDAC. The study included all patients with clinical stage I and II PDAC from the National Cancer Database who underwent surgical resection between 2004 and 2020; complete data were available for 24,260 patients with stage I PDAC and 23,850 patients with stage II PDAC. When pathologic stage, obtained at surgery, was higher than clinical stage, patients were considered upstaged.
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