Reporting from the UK: Evidence Lacking for Gender Dysphoria Treatments for Teens

Evidence is lacking for use of puberty blockers and hormone treatment for gender dysphoria/incongruence, according to two systematic reviews published online April 10 in the Archives of Disease in Childhood.

Jo Taylor, Ph.D., from the University of York in the United Kingdom, and colleagues conducted a systematic review and meta-analysis to examine the evidence for use of treatment to suppress or lessen the effects of puberty among adolescents experiencing gender dysphoria/incongruence. Data were included from 50 studies. The researchers found consistent evidence demonstrating efficacy for suppressing puberty. In multiple studies, there was an increase in height, although not in line with expected growth. Reductions in bone density were reported during treatment in multiple studies. In relation to gender dysphoria, psychological and psychosocial health, body satisfaction, cardiometabolic risk, cognitive development, and fertility, the evidence was limited and/or inconsistent.

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