Newly reported from the UK: Collagenase Not Noninferior for Dupuytren Contracture

For patients with moderate Dupuytren contracture, collagenase injection is not noninferior to limited fasciectomy, according to a study published online Oct. 9 in the New England Journal of Medicine.

Joseph Dias, M.D., from Leicester General Hospital in the United Kingdom, and colleagues conducted a pragmatic, randomized, controlled, noninferiority trial comparing collagenase injection to limited fasciectomy among individuals with moderate Dupuytren contracture. The score on the Patient Evaluation Measure-Hand Health Profile (PEM), as reported by the patient at one year after treatment, was the primary outcome.

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