From the USA: Harmful Association Identified Between Traffic Pollution, Amyloid Plaques

Traffic-related fine particulate matter (PM2.5) affects the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) score, according to a study published online Feb. 21 in Neurology.

Grace M. Christensen, Ph.D., from the Emory University School of Medicine in Atlanta, and colleagues conducted a cross-sectional study using 224 brain tissue donors who died before 2020. Alzheimer disease (AD) pathology was assessed among donors using the Braak stage, CERAD score, and combined AD neuropathologic change (ABC) score. The association between traffic-related PM2.5 (based on measurements of one-, three-, and five-year average PM2.5 concentrations before death matched to home addresses) and AD hallmark pathology was examined.

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