Directly from the USA: Metabolic Surgery Is Renoprotective in Patients With Obesity, CKD

For patients with obesity, type 2 diabetes, and estimated glomerular filtration rate (eGFR) 20 to 60 mL/min/1.73 m2, metabolic surgery is associated with a lower risk for progression of kidney impairment compared with glucagon-like peptide-1 receptor agonist (GLP-1RA) treatment, according to a study published in the September issue of the Annals of Surgery.

Ali Aminian, M.D., from the Cleveland Clinic, and colleagues examined the renoprotective effects of metabolic surgery in patients with established chronic kidney disease (CKD). Patients with obesity, type 2 diabetes, and eGFR 20 to 60 mL/min/1.73 m2 who underwent metabolic surgery were compared to nonsurgical patients who received GLP-1RA treatment. The analyses included 425 patients: 183 in the metabolic surgery group and 242 in the GLP-1RA group, with a median follow-up of 5.8 years.

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