Directly from the UK: Surgery for Isolate Cleft Palate at 6 Months Yields Better Outcomes Than at 12 Months

Medically fit infants who underwent primary surgery for isolated cleft palate in adequately resourced settings at 6 months of age were less likely to have velopharyngeal insufficiency at 5 years of age versus those who had surgery at 12 months of age, according to a study published in the Aug. 31 issue of the New England Journal of Medicine.

Carrol Gamble, Ph.D., from University of Liverpool in the United Kingdom, and colleagues randomly assigned (1:1) infants with nonsyndromic isolated cleft palate to undergo standardized primary surgery at 6 months of age or at 12 months of age for closure of the cleft. The analysis included 558 infants treated at 23 centers across Europe and South America.

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